Sega Game Gear ROMs
Letter: S
- S.S. Lucifer - Man Overboard!
- Samurai Shodown
- Samurai Spirits
- Scratch Golf
- SD Gundam - Winner's History
- Sega Game Pack - 4 in 1
- Shadam Crusader (Japan)
- Shanghai 2
- Shaq Fu
- Shikinjou (Japan)
- Shining Force Gaiden - Final Conflict
- Shining Force II - The Sword of Hajya
- Shinobi II - The Silent Fury
- Simpsons - Bart vs. the Space Mutants
- Simpsons - Bart vs. the World
- Simpsons - Bartman Meets Radioactive Man
- Skweek
- Slider
- Smash T.V.
- Smurfs
- Solitaire Funpak
- Solitaire Poker
- Sonic & Tails
- Sonic & Tails 2
- Sonic Blast
- Sonic Chaos
- Sonic Drift
- Sonic Drift 2
- Sonic Labyrinth
- Sonic Spinball
- Sonic the Hedgehog
- Sonic the Hedgehog - Triple Trouble
- Sonic the Hedgehog 2
- Soukoban (Japan)
- Space Harrier
- Spider-Man - Return of the Sinister Six
- Spider-Man and X-Men - Arcade's Revenge
- Spider-Man vs. the Kingpin
- Sports Illustrated - Championship Football & Baseball
- Sports Trivia
- Sports Trivia - Championship Edition
- Star Trek Generations - Beyond the Nexus
- Star Trek TNG - Advanced Holodeck Tutorial
- Star Wars
- Star-Gate
- Streets of Rage
- Streets of Rage 2
- Strider Returns
- Super Columns
- Super Golf
- Super Kick Off
- Super Monaco GP
- Super Off-Road
- Super Return of the Jedi
- Super Space Invaders
- Superman
- Surf Ninjas
- Sylvan Tale